Senior Director, Nonclinical Toxicology

Senior Director, Nonclinical Toxicology Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease. The Opportunity Design and management of exploratory and GLP toxicology and safety pharmacology studies. Handle multiple projects in a timely and effective manner at various stages of discovery, preclinical, and clinical development. Write, interact, and/or contribute to all applicable Regulatory Documents/Authorities and Asset Teams. Lead toxicology strategy and tactics in discovery, preclinical development and clinical development with a focus on understanding/assessing the human risk of novel therapeutic targets and/or understanding mode of action for toxicity in nonclinical studies Participate in multi-disciplinary team efforts and implement program-specific toxicology strategies to support compound and program progression Monitor outsourced GLP and non-GLP studies ensuring compliance with the protocol, amendments, regulations, safety guidelines, and standard operating procedures Write and review toxicology protocols, reports, and documentation for regulatory filings, and participate in regulatory interactions Apply a broad understanding of toxicology, pharmacology, ADME, and knowledge of applicable regulatory guidelines to the design of appropriate toxicology studies and development plans Provide cr