Senior Research Associate, Preclinical Pharmacology

Senior Research Associate, Preclinical Pharmacology Run in vivo studies that move Nurix's degrader programs toward the clinic. You'll execute mouse efficacy, PK/PD, and mechanism-of-action studies in oncology and inflammation models and generate the Western blot and flow cytometry data that show how our molecules work. Position Description The Opportunity Join the Research – Preclinical Pharmacology team as a full-time, onsite, hands-on member, reporting to a Scientist / Principal Scientist, Preclinical Pharmacology Perform mouse handling and in-life procedures, including dosing by oral (PO), intraperitoneal (IP), subcutaneous (SC), and intravenous (IV) routes, tumor cell implantation, tumor and body-weight measurements, and in-life and terminal blood collection Execute PK/PD, tolerability, and efficacy studies in oncology xenograft/syngeneic models and in murine models of inflammation, under the direction of study leads Prepare and formulate test articles and vehicles for dosing; monitor animal health, document observations, and escalate adverse events promptly Perform necropsy and collect, process, and bank tissues and blood for downstream biomarker and pharmacodynamic analyses Prepare tissue and cell lysates and perform Western blotting (including quantitative and automated capillary formats) to measure target degradation and pathway modulation Develop, run, and analyze multi-color flow cytometry panels for immune and tumor-cell phenotyping from blood, spleen, tumor, and other tissues Maintain and expand cell lines using sterile cell culture technique; support cell-based assays and the generation of cells for in vivo implantation Record experiments accurately and in a timely manner in the electronic lab notebook; analyze, graph, and summarize data and present results at team meetings Collaborate with Biology, Chemistry, DMPK, and Translational teams to design studies and troubleshoot models and assays Adhere to IACUC protocols, animal welfare regulations, and lab