Senior Scientist, Medicinal Chemistry

Senior Scientist, Medicinal Chemistry Drive medicinal chemistry strategy for Nurix's discovery programs, from hit optimization through development candidate nomination. You'll design novel compounds, interpret complex SAR across multidisciplinary datasets, and help set new scientific directions, with opportunities to lead chemistry workstreams and mentor colleagues. Position Description The Opportunity Design novel chemical entities and medicinal chemistry strategies, applying structure-based drug design to optimize potency, selectivity, physicochemical properties, ADME/PK, safety, and in vivo efficacy Design synthetic strategies for complex molecules using modern and creative synthetic methods Develop and interpret SAR by integrating chemical, structural, computational, biochemical, cellular, pharmacological, and ADME/PK data; independently identify key questions, design experiments, and recommend compound or series advancement, redesign, or termination Partner closely with computational chemists, structural biologists, and colleagues across biology, pharmacology, and DMPK to advance project objectives Develop innovative concepts that establish new directions and address complex challenges, drawing on emerging literature, patents, and competitive intelligence to inform compound design and strategy Lead chemistry workstreams within multidisciplinary teams, independently manage priorities and external collaborations, and contribute to project strategy and key scientific decisions Provide scientific guidance, coaching, and mentorship to other scientists Communicate scientific rationale, data, and recommendations clearly to project teams, leadership, and broader scientific audiences Contribute to intellectual property generation, patent preparation, and scientific publications; represent assigned projects at external forums; and lead improvements in laboratory practices and workflows What You’ll Bring BS or MS with 14+ years of relevant experience, or PhD with 8+ years